We very commonly encounter anxiety and depression both as a cause and as the effect of medical conditions. Work stress, economic stress, family and relationship issues, fear of aging and deterioration, Retirement issues, isolation and loneliness, and sexual issues have been exacerbated by Covid, crime, and political instability. In addition to referring to therapists and psychiatrists and providing appropriate medication, Castle Connoly offers free of charge the CCPHP SENS program for stress reduction. In appropriate circumstances we are prepared to discuss supplements, recommend Julia Ross’ book The Mood Cure as a reference, refer for Ketamine therapy, and are interested in the research involving microdosing psychedelics.